Saturday, April 22, 2023

Uracil in asteroid

 

The discovery of uracil by Japanese space agency’s Hayabusa2 mission from Ryugu (a near earth asteroid found within the asteroid belt between Mars and Jupiter) last month was a significant advancement in understanding origin of life on earth. The technical complexity and dexterity displayed in this feat included precision separation of the spacecraft’s collision equipment, called a small carry-on impactor (SCI), and firing the bullet so that it accurately struck Ryugu’s surface, to the probe’s maneuvering in retreat to a position behind the asteroid to avoid getting hit by flying shards from the blast, collection of samples ejected by the blast which were then brought back to Earth for analysis. It’s an amazing achievement. The reason why am I writing this now is in the context to ‘rapid unscheduled disassembly’ as described by SpaceX team when it apparently, and very evidently, exploded -in full view of millions of viewers, a spectacle that was also a compelling metaphor for people involved. Social media went hysterical over this description, and I too brought in my worst side of sarcasm. Someone responded that ‘this is how science progresses, by failures and learning…”, another fellow called me ‘evil’ so on. Well to start with this is not science -in its fundamental research or intention or abstract values, but just an application. It’s a market display of applied technology. Also, the spectacle was arranged by a narcist billionaire to showcase his grand plans. The fellow is essentially Trump of tech world, an unchecked incrementalised flaw of self-referenced reverential system controlled and manipulated by few. A mechanistic and reductive evaluation of humanity, product of incomplete education. An pubescent market mind in juvenile excited brain trapped in middle aged body. He has displayed enough reasons for us to be extremely wary, and be alarmed by the influence in narration. Indeed, he is a necessary pause in evaluating hedonistic system created narcistic agendas of fragile egos that lack nuance or awareness, that lack necessary existential humbleness when dealing with awe inspiring forces and brilliance of nature. The loud, the crude, the crass, afflicted with pointers of market spectacle can garner attention, hence money, but will fall well short in the scale of complexity of infinite and subtlety of moment. Matter of research is about meticulous attention and care, and essential awareness of context and complex links. A true researcher will be always in awe.

Discovering uracil in an asteroid is evidence that strengthens theory of extraterrestrial origin of life. It’s an amazing find and culmination of meticulous research by scientists. Basic school science will tell you that RNA has three letters i.e. nucleotides same as DNA (not going into the detail) except Thymine. RNA has Uracil. Flow of genetic information happens from DNA to RNA (through transcription) to protein (through translation), and this is the central dogma of molecular biology. Every three letters of RNA when read together equals one amino acid, so a sequence of nucleotides from gene is equal to sequence of amino acid in protein. In 1980s Tom Cech, US based scientist, discovered self-splicing ribozymes, a breakthrough discovery because the existence of self-splicing ribozymes suggested that life on earth arose from molecules of RNA that could both encode genetic information and replicate that information in primitive cells. RNA achieves this spectacular feat of both as a repository of genetic instructions and chemically reactive molecule capable of changing shape and biological behavior as it can fold up into three-dimensional structure, unlike DNA which is double helix.